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The principal cytochrome P450 isoenzyme concerned appears for being CYP2E1, with CYP1A2 and CYP3A4 as more pathways. About 85% of the oral dose appears within the urine inside of 24 hours of administration, most because the glucuronide conjugate, with little quantities of other conjugates and unchanged drug.There won't be any common opioid tapering